Thus, the metabolite is chargeable for about 20% of sildenafil's action. Sildenafil is excreted as metabolites predominantly from the feces (about 80% of administered oral dose) and to a lesser extent inside the urine (about 13% on the administered oral dose). If taken which has a high-fat food, absorption is decreased; the time taken to reach the maximum plasma focus improves by around 1 hour, and the most focus alone is diminished by approximately a person-third.[fifty two]
Even though the interaction among other protease inhibitors and sildenafil has not been analyzed, their concomitant use is predicted to increase sildenafil amounts.
VIAGRA could potentially cause your hypertension to drop suddenly to an unsafe degree if it is taken with specified other medicines. Usually do not get VIAGRA if you take any other medicines identified as “nitrates.
Do not take sildenafil Unless of course it has been prescribed to you personally by a Health care service provider. Take it as prescribed.
I tilfelle leverproblemer eller medisinsk historie, del det med legen din og apoteket for å få den justerte dosen eller en alternativ medisin for å behandle din medisinske tilstand.
The use of sildenafil and an α1 blocker (normally prescribed for hypertension or for urologic situations, which include benign prostatic hypertrophy) concurrently may well bring on lower blood pressure level, but this result will not occur Should they be taken not less than four several hours apart.[29]
Sildenafil was reclassified in New Zealand in 2014 so it could be acquired in excess of the counter from a pharmacist. It is thought this minimized sales over the Internet and was safer as males could be referred for professional medical advice if ideal.[119]
In Individuals individuals already getting an optimized dose of a PDE5 inhibitor, alpha-blocker therapy should be initiated at the bottom dose. Stepwise increase in alpha-blocker dose may very well be connected to more decreasing of blood pressure when using a PDE5 inhibitor.
The following gatherings occurred in < two% of individuals in managed clinical trials; a causal romance to VIAGRA is uncertain. Described events include things like Individuals that has a plausible relation to drug use; omitted are small functions and reports too imprecise to become significant:
VIAGRA will not be indicated for use in women. There are no enough and properly-controlled experiments of sildenafil in pregnant Gals.
Medical professionals really should explore with clients the enhanced danger of NAION in people who have by now knowledgeable NAION in a single eye. Physicians also needs to go over with people the greater risk of NAION between the final population in sufferers with a “crowded” optic disc, Despite the fact that proof is inadequate to assistance screening of potential people of PDE5 inhibitor, including VIAGRA, for this uncommon problem [see WARNINGS AND Safeguards and ADVERSE REACTIONS].
På den annen facet, mens det er den aktive ingrediensen i Viagra, er Sildenafil tilgjengelig som en generisk versjon av Viagra laget av flere produsenter. Det betyr at prisen på Sildenafil generelt er lavere enn more info prisen på Viagra.
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Lots of of such situations ended up documented to happen throughout or Soon right after sexual activity, and some ended up documented to occur Soon just after the use of VIAGRA without the need of sexual action. Others have been claimed to possess transpired hrs to times after the usage of VIAGRA and sexual exercise. It is not possible to determine no matter if these events are related on to VIAGRA, to sexual activity, into the patient's fundamental heart problems, to a combination of these components, or to other variables [see WARNINGS AND Safeguards and Affected person Info].